In one case, the issue resolved after supplement discontinuation. Another recent study found that red clover inhibited the growth of normal prostate cells and increased the resistance of prostate cancer cells to high-dose radiation in vitro. Biochanin A protects dopaminergic neurons against lipopolysaccharide-induced damage through inhibition of microglia activation and proinflammatory factors generation. Also known as: Daidzein, genistein, isoflavone, phytoestrogen, purple clover, trefoil, trifolium, beebread, clovone. Dietary isoflavone intake also improved arterial compliance, an index of large artery elasticity which is an important cardiovascular risk factor (12). The loss of elasticity can contribute to increased blood pressure, causing the heart to work harder. Three: Blood flow seems to be enhanced by this herb since it can help prevent blood clots and thins the blood. Red Clover roots have also been used to treat diphtheria. Atkinson C, Compston JE, Day NE, et al. The controversy concerning the use of red clover for the treatment of cancer is twofold. Donate today. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. 2007(4):CD001395. and anti-osteoporotic effects, as well as for their ability to relieve menopausal symptoms. Red clover extract can stimulate the production of estrogen receptor-positive breast cancer cells in lab experiments. Red clover is used to treat cancer as well as respiratory problems such as asthma, whooping cough and bronchitis. In red clover blossoms, the compounds biochanin-A, caffeic acid, chlorogenic acid, coumarin, formononetin, genistein and isorhamnetin all demonstrate some anti-cancer … However, compared to estrogen, which has relative high binding affinity for the ER-α and ER-β, isoflavones demonstrate up to ~1600 times lower affinity for ER-α meaning they should not increase the risk of cancer. 2005;21:257-64. Acute-on-chronic subdural hematoma in a patient taking Red Clover herbal supplement: A case report. Potential uses: Red clover is used to treat menopausal symptoms and breast pain.  However, the red clover isoflavone biochanin A was shown to inhibit aromatase activity and expression, thereby conferring a protective effect. I say this because a lot of women are simply going to think that red clover is completely safe. Red clover: Red clover has been hailed as "the" herb for cancer by many herbalists. Simultaneous determination of the inhibitory potency of herbal extracts on the activity of six major cytochrome P450 enzymes using liquid chromatography/mass spectrometry and automated online extraction. 2008;99:303-10. Cow clover, wild clover, purple clover, beebread, cow grass, meadow clover, purple clover. Data on red clover’s potential for reducing the symptoms of menopause and for decreasing the risk of breast cancer are inconclusive. It also stopped the growth of normal prostate cells and increased prostate cancer cell resistance to high-dose radiation. Neurocrit Care. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. Red Clover Uses. The phytoestrogenic properties of the isoflavones in red clover are why it is not recommended for use by women who’ve been diagnosed with breast cancer, without first discussing it with their physician. If youve wondered what benefit this herb has, youre not alone. Red clover is an herbal supplement used orally for conditions such as menopausal symptoms and hot flashes, mastalgia, premenstrual syndrome, cancer prevention, indigestion, hypercholesterolemia, whooping cough, asthma, bronchitis, and sexually transmitted diseases.. Topical use of red clover includes for cancer, skin sores, burns, sore eyes, and chronic skin diseases including eczema. Isoflavones have generated considerable interest in the last decade because of their possible cancer-preventive, cardioprotective. The effect of red clover isoflavone supplementation over vasomotor and menopausal symptoms in postmenopausal women. Red clover is one of the richest sources of isoflavones. Red clover traditional medicine uses. Red clover is a perennial herb traditionally used to treat skin disorders such as psoriasis and eczema, whooping cough, and mastitis. Si vous êtes en période de ménopause, vous avez peut-être envisagé les thérapies hormonales afin de réduire les symptômes les plus gênants. Lukaczer D, Darland G, Tripp M, et al. Comme vous le savez probablement, ces thérapies médicamenteuses font l'objet de discussions multiples aujourd'hui, car elles sont associées à une augmentation du risque de cancer du sein. One: The isoflavones that are contained in the herb may help raise HDL cholesterol (the good kind). Red clover is used in Turkish folk medicine as expectorant, antiseptic, analgesic properties and as a treatment for rheumatic aches. In postmenopausal women, endometrial status was not adversely affected. Friedman JA, Taylor SA, McDermott W, Alikhani P. Multifocal and recurrent subarachnoid hemorrhage due to an herbal supplement containing natural coumarins. It also inhibited proliferation of human osteosarcoma U2SO cells by decreasing expression of miR-375 and Bcl-2, an apoptotic repressor, while increasing Bax, a pro-apoptotic protein (27). Red clover (Trifolium pratense) is a medicinal herb containing flavonoids, coumarins, coumestans, and isoflavones. The isoflavone Biochanin A inhibited activity and gene expression of aromatase, an enzyme that catalyzes the conversion of androgen to estrogen (2). It turns out that the isoflavones in red clover may possess antitumor activity in the test tube. In the best selling herbal classic Back to Eden, author Jethro Kloss declares red clover as a life-saving anti-cancer remedy. Health-related information changes frequently and therefore information contained on this Web site may be outdated, incomplete or incorrect. More studies are needed. Memorial Sloan Kettering does not assume any risk whatsoever for your use of this website or the information contained herein. Compounds in red clover include phytoestrogenic isoflavones such as genistein, diadzen, formononetin and biochanin A. Also, red clover may increase the effects of anticoagulants and antiplatelet drugs. It contains compounds known as isoflavones that act as phytoestrogens. Studies suggest it is not effective in treating hot flashes. 7. Hidalgo LA, Chedraui PA, Morocho N, et al. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. [1,2,3] However, conclusions from systematic reviews have been conflicting: one suggested marginal benefit, whereas another found no evidence of effectiveness. While historically the RC plant has been taken in the form of tea and tinctures, today it’s often used to make extracts, such as the products … Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. J Clin Endocrinol Metab. Data from clinical trials suggest that supplementation with red clover isoflavones helps relieve menopausal symptoms. Formononetin, an isoflavone, induced apoptosis in human breast cancer cells by activating the Ras-p38 mitogen-activated protein kinase in ER-positive breast cancer cells (23). Patients with hormone-sensitive cancers should avoid red clover because it has estrogenic activity, Red clover may increase effects of anticoagulants and antiplatelet drugs, Red clover causes toxic effects when used with methotrexate, © 2020 Memorial Sloan Kettering Cancer Center, Gerstner Sloan Kettering Graduate School of Biomedical Sciences, Integrative Medicine at Home Membership Program. The isoflavones present in red clover have estrogen-like effects and have been the subject of intense research over the last decade. Phytomedicine. A meta-analysis of a standardized extract suggests potential reductions in total cholesterol in peri- and postmenopausal women, but studies were heterogeneous (29). . To prevent pregnancy, be sure to use an additional form of birth control while using red clover leaf extract. Prostate-specific natural health products (dietary supplements) radiosensitize normal prostate cells. Red clover has also been contraindicated with heparin, ticlopidine, and warfarin, based on its coumadin content. Wang Y, Man Gho W, Chan FL, et al. Clinical relevance has yet to be determined.Methotrexate: Red clover was reported to cause toxicity, resulting in severe vomiting and epigastric pain, when used along with methotrexate injections (19). The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Red Clover is one of the ingredients s of the ‘controversial Hoxsey cancer treatment,’ developed by Harry Hoxsey in the 1920’s. Studies on whether red clover may help reduce menopausal symptoms are mixed, and additional study is needed to confirm positive effects and safety with long-term use. Neuroprotective mechanisms of red clover and soy isoflavones in Parkinson's disease models View ORCID Profile Aurelie de Rus Jacquet , Abeje Ambaw , View ORCID Profile Mitali A Tambe , Michael Timmers , Sin Ying Ma , Qing-Li Wu , James E Simon , George P McCabe , Mary Ann Lila , Riyi Shi , View ORCID Profile Jean-Christophe Rochet Today, extracts from red clover are most often promoted for menopause symptoms, high cholesterol levels, or osteoporosis. Red clover does not significantly reduce total or LDL cholesterol, or increase HDL in women 49-65.  In other studies, red clover isoflavones reduced bone loss and improved arterial compliance (the latter is an index of the elasticity of large arteries, an important cardiovascular risk factor). Am J Clin Nutr. Le Bail JC, Champavier Y, Chulia AJ, Habrioux G. Effects of phytoestrogens on aromatase, 3beta and 17beta-hydroxysteroid dehydrogenase activities and human breast cancer cells. Though rare, potential side effects include vaginal spotting, prolonged menstruation, skin irritation,... At-risk populations. Red clover is a perennial herb traditionally used to treat skin conditions such as... ALSO KNOWN AS: . However, unless red clover herb is fermented, it is unexpected to have any anticoagulant effects. Red Clover tea, made from the red blossoms, was an old remedy for winter colds. It also stopped the growth of normal prostate cells and increased prostate cancer cell resistance to high-dose radiation. Gynecol Endocrinol. But as you can see hormone support for her helps in treating cancer such as breast cancer if used before actually getting the cancer. Red clover is used in the treatment of skin complaints (especially eczema and psoriasis), cancers of the breast, ovaries and lymphatic system, chronic degenerative diseases, gout, whooping cough and dry coughs. Cattle and other animals graze on red clover. Altern Ther Health Med. Usual dose: To relieve hot flashes, an extract of 40 to 160 milligrams per day has been used. The treatment of cancer with Red Clover has a great many advocates and has been with us for a long time. Dried red clover flowers have been used in traditional medicine to treat a wide variety of ailments, including jaundice, cancer, breast tissue infections, joint disorders, and respiratory conditions (e.g, whooping cough, bronchial asthma), and as a sedative. Br J Nutr. Red clover contains compounds known as isoflavones that act as phytoestrogens. Red clover contains substances called isoflavones. All rights reserved. Red clover causing symptoms suggestive of methotrexate toxicity in a patient on high-dose methotrexate. The effect of red clover isoflavones on menopausal symptoms, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Red clover is a wild plant belonging to the legume family. 2005;11:60-65. © 2020 MJH Life Sciences and Cancer Network. Do not take red clover if on a blood thinner, or when using melilot an herb that enhances bleeding. CONTRAINDICATIONS AND ADVERSE REACTIONS: Patients with hormone-sensitive cancers should avoid red clover because of its estrogenic activity. Biochanin A (BCA) is a dietary isoflavone present in red clover. Note, however, that research hasn't shown that the herb is conclusively effective for these or any other health concerns. Red clover has long been used as a “blood purifier,” specifically for the potential treatment of cancer. Isoflavones are phytoestrogens—compounds similar to the female hormone estrogen. 5. Formononetin induces apoptosis of human osteosarcoma cell line U2OS by regulating the expression of Bcl-2, Bax and MiR-375 in vitro and in vivo. 2007;7:76-80. Red clover contains isoflavone compounds similar to those found in soy. Because red clover contains isoflavones that mimic the effects of the hormone estrogen once they enter the body, the safety of RC in patients with breast or endometrial cancer remains controversial. Red clover contains the anticoagulant and blood-thinning compound coumarin. It has also been used medicinally to treat several conditions including cancer, whooping cough, respiratory problems, and skin inflammations, such as psoriasis and eczema. 2004;79:326-33. Red Clover for Bigger Breast – Side Effects. 2010;76:896-904. Red clover may also block enzymes thought to contribute to prostate cancer in men. Red clover is a reserve of protein and unique phytochemicals. 10. All rights reserved. Nourishing food herbs like Red Clover have been used for thousands of years with no indication the plant contributed to estrogen dominant conditions or estrogen-sensitive cancers.